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An acceptable route for a certified caregiver to administer medication is

  1. Injection (intramuscular)

  2. Oral (by mouth)

  3. Ophthalmic (eye)

  4. Topical (on the skin)

The correct answer is: Ophthalmic (eye)

A certified caregiver may administer medication through various routes depending on the specific circumstances and the type of medication. The intramuscular (A), oral (B), and topical (D) routes mentioned in the other options are acceptable routes, but they may not be the most appropriate or safe option for all medications. Ophthalmic (C) refers specifically to administering medication through the eye, which is often necessary for certain types of eye drops or ointments. This route should only be used by a certified caregiver who has been trained and authorized to administer medication through the eye. It is important to follow proper protocols and guidelines when administering medication to ensure the safety and well-being of the patient.